Molecular Determinants for the Chemical Activation of the Warmth-Sensitive TRPV3 Channel by the Natural Monoterpenoid Carvacrol

    February 2022 in “ Journal of Biological Chemistry ”
    Canyang Niu, Xiaoying Sun, Fang Hu … KeWei Wang
    Studysummary This study found that carvacrol activates the TRPV3 ion channel by binding to a specific pocket formed by the S2-S3 linker, providing insight into its role in skin sensitization and potential for designing specific modulators.
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    Research cited in this study 3

    1. Therapeutic Inhibition of Keratinocyte TRPV3 Sensory Channel by Local Anesthetic Dyclonine 2020
    2. Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3 Journal of Investigative Dermatology · 2014
    3. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007