TLDR Toluene diisocyanate exposure can cause immune sensitization by interacting with proteins in hair follicles and sebaceous glands.
The study investigated the immune sensitization caused by skin exposure to toluene diisocyanate (TDI) using a murine model. BALB/c mice were exposed to TDI, and analyses revealed that TDI-haptenated proteins (TDI-hp) localized in the stratum corneum, hair follicles, and sebaceous glands. These proteins co-localized with immune cells such as CD11b(+), CD207(+), and CD103(+) in hair follicles and sebaceous glands, indicating these areas as reservoirs for TDI-hp. The study identified cytoskeletal and cuticular keratins and mouse serum albumin as major haptenated species, suggesting a mechanism for immune recognition and potential sensitization following TDI exposure.
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