Final Report on the Safety Assessment of Human and Animal Placental and Umbilical Extracts in Cosmetics

April 2002 in “ International Journal of Toxicology ”

Bindu R. Nair, Amy Elmore

human placental protein hydrolyzed human placental protein human placental enzymes human placental lipids human umbilical extract placental protein hydrolyzed placental protein placental enzymes placental lipids umbilical extract estrogenic activity biological activity skin sensitization toxicity photosensitization genotoxicity ocular toxicity metabolic activity endocrine activity

TLDR The safety of placental and umbilical extracts in cosmetics is uncertain, requiring more research.

The report assessed the safety of various human and animal placental and umbilical extracts used in cosmetics. It found that human-derived ingredients, except for Human Placental Protein, were prohibited in the EU due to disease transmission concerns. Animal-derived placental proteins, hydrolyzed proteins, lipids, and enzymes were in use, but no current uses of umbilical extracts were reported. Most data indicated potential estrogenic or biological activity, but one clinical study showed no irritant reaction. The report concluded that available data were insufficient to ensure safety, recommending further studies on skin sensitization, toxicity, photosensitization, genotoxicity, and ocular toxicity. It emphasized that cosmetic ingredients should not have metabolic/endocrine activity and must be free of pathogens.

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