Acute Dermal and Ocular Irritation Testing of Rice Bran Supercritical CO2 Extract (RB-SCE) and 0.5% RB-SCE Essence Product

    March 2015 in “ Toxicology and Environmental Health Sciences ”
    Jae‐Suk Choi, Jin-Nam Moon, Woi-Sook Moon, Eun Jin Cheon, Joowan Kim, Mi-Ryung Kim
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    TLDR Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.
    The study evaluated the irritation potential of rice bran supercritical CO2 extract (RB-SCE) and a 0.5% RB-SCE essence product on the skin and eyes of rabbits and guinea pigs. RB-SCE was found to cause moderate skin irritation with a primary irritation index (PII) of 2.71 in rabbits, but it was classified as a non-irritant for the eyes. The 0.5% RB-SCE essence did not cause skin irritation in rabbits (PII of 0) and was considered a very weak irritant in guinea pigs, with a 0% sensitization rate. The study, which followed OECD guidelines and Good Laboratory Practice, involved 9 rabbits for the ocular toxicity test, 6 rabbits for the acute dermal toxicity test, and 20 guinea pigs for the skin sensitivity test of the essence. The research suggests that RB-SCE and its essence are safe for use in cosmetic and pharmaceutical applications at moderate doses, and was supported by a grant from the Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea.
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