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research Acute dermal and ocular irritation testing of rice bran supercritical CO2 extract (RB-SCE) and 0.5% RB-SCE essence product

2 citations , March 2015 in “Toxicology and Environmental Health Sciences”

This study found that rice bran supercritical CO₂ extract was classified as a non-irritant for ocular use but a moderate irritant for dermal use in rabbits and guinea pigs.

research Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

May 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This review examines recent advancements in topical formulations for alopecia treatment, but it reports no new clinical results, emphasizing potential strategies to enhance drug delivery to the scalp.

research The early changes in mouse skin following topical application of a range of middle distillate oil products

19 citations , July 1993 in “Journal of Applied Toxicology”

This study found that various petroleum distillates caused significant skin changes in mice, with severity varying based on the product and penetration pathway, potentially leading to skin tumors through non-genotoxic mechanisms in longer-term exposure.

research 519 Design of a new molecule proven to be safe and effective for topical depigmenting and antiaging method

November 2022 in “Journal of Investigative Dermatology”

This study developed a chalcone-based molecule that significantly increased tyrosinase inhibition and solubility, showing potential as a safe and effective skin depigmenting and antiaging agent, with supportive epigenetic and antioxidant properties observed in vitro.

research Minoxidil

October 2015 in “Elsevier eBooks”

Minoxidil is effective for hair growth and safe for long-term use.

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Community Join

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community M25 - Need Non alcoholic minoxidil options available in India

1 upvotes 4 months ago

The conversation is about finding non-alcoholic minoxidil options in India due to irritation from propylene glycol-based formulations. Suggestions include Tugain 5% foam, Morr Max 5%, minoxidil gel, and Morr F Aqua plus, with OP avoiding finasteride due to side effects.

community Best way to limit scalp irritation with topical fin?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The user is experiencing scalp irritation from a compounded treatment of finasteride, minoxidil, and tretinoin. They are considering switching to a non-alcohol, propylene glycol-free formula with a lower tretinoin percentage to reduce irritation.

community Be careful about using non-PG based alternatives of Minoxidil (mathematically speaking, haven’t seen much practical studies)

in Research/Science 7 upvotes 1 month ago

Minoxidil formulations often use propylene glycol (PG) for stability and effectiveness, but PG-free alternatives like foams and PEG-based solutions can also be effective with less irritation. Concerns exist about the quality of PG-free minoxidil from lesser-known brands, especially from India, due to potential manufacturing issues.

community What can I use to prepare a lotion that doesn't irritate my scalp or make my hair sticky? (Want to experiment with metformin and Alpha Keto glutarate)

2 upvotes 2 years ago

The conversation is about a user who tried dissolving a metformin pill in water for hair treatment but faced issues with hair sticking together. The user is seeking advice on preparing a non-irritating, non-sticky lotion at home, possibly experimenting with metformin and Alpha Keto glutarate.

community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.

18 upvotes 1 year ago

Different minoxidil formulations affect hair growth and side effects. Higher propylene glycol and pH levels improve effectiveness but can cause scalp irritation.

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Learn

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learn GHK-Cu

GHK-Cu: Does it have side effects or is it completely safe? For topical cosmetic use, the small laboratory evidence base found GHK-Cu non-irritating, and reported reactions are local and uncommon; for injected or oral use there is effectively no human safety data, and the FDA lists GHK-Cu among bulk substances that may present significant safety risks in compounding.

learn Overview

learn Thymosin Beta 4

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

What are the non-surgical alternatives to hair transplants? Non-surgical alternatives include PRP therapy, medications, laser therapy, and scalp micropigmentation.

learn Allantoin

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