Design of a New Molecule Proven to Be Safe and Effective for Topical Depigmenting and Antiaging Method
November 2022
in “
Journal of Investigative Dermatology
”
Studysummary This study developed a chalcone-based molecule that significantly increased tyrosinase inhibition and solubility, showing potential as a safe and effective skin depigmenting and antiaging agent, with supportive epigenetic and antioxidant properties observed in vitro.
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The study aimed to develop a safe and effective skin depigmenting and antiaging agent. Two chalcone-based molecules were synthesized and tested for their tyrosinase inhibition and solubility. One molecule, 5-[(E)-3-(4-hydroxyphenyl)acryl]-2-hydroxybencensulfonic acid, showed promising results. It increased tyrosinase inhibition 2-fold compared to the reference and improved solubility by over 80 times. It was also found to be non-cytotoxic and non-irritant, and it reduced melanin content by 51%. The molecule also demonstrated antiaging activity by showing antioxidant, antiglycation, and autophagy efficacy. The results suggest that this molecule could be a suitable candidate for use as a safe and effective depigmenting and antiaging agent in dermatology or cosmetics.
