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Glossary Sensitization

immune system becomes overly reactive to a substance

Sensitization refers to the process by which the immune system becomes overly reactive to a substance, often leading to allergic reactions. For example, in the context of hair and scalp health, repeated exposure to certain hair dyes or chemicals can cause the immune system to recognize these substances as harmful, resulting in inflammation or allergic dermatitis upon subsequent exposures.

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Research

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research Acute dermal and ocular irritation testing of rice bran supercritical CO2 extract (RB-SCE) and 0.5% RB-SCE essence product

2 citations , March 2015 in “Toxicology and Environmental Health Sciences”

This study found that rice bran supercritical CO₂ extract was classified as a non-irritant for ocular use but a moderate irritant for dermal use in rabbits and guinea pigs.

research An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice

36 citations , June 2015 in “International journal of toxicology”

This study established a new mouse model for TCE-induced skin sensitization and reported that proinflammatory cytokines TNF-α, IFN-γ, and IL-2 significantly contribute to this sensitization process.

research Indications for Peripheral and Central Sensitization in Patients With Chronic Scalp Pain (Trichodynia)

16 citations , December 2012 in “The Clinical Journal of Pain”

This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.

research Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients

February 2025 in “Journal of Cosmetic Dermatology”

This study examined the sensitization potential of common hair care products and found that certain ingredients, like cobalt chloride and nickel sulfate, frequently cause allergic reactions in individuals with hair diseases, providing essential insights for personalized treatment strategies.

research A systematic review on the treatment of pediatric severe alopecia areata by topical immunotherapy or Anthralin (contact sensitization) or low‐level light/laser therapy (LLLT): focus on efficacy, safety, treatment duration, recurrence, and follow‐up based on clinical studies

17 citations , October 2021 in “Journal of Cosmetic Dermatology”

This review found that topical immunotherapy and light/laser therapy may achieve over 50% hair regrowth efficacy in treating extensive alopecia areata in children, with no serious side effects observed.

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community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community Quit finasteride after 15+ years

972 upvotes 1 year ago

A user stopped finasteride after 15 years due to severe side effects, which improved after quitting. They maintained most of their hair and are considering alternatives like topical treatments or RU58841.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 1 year ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

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learn Thymosin Beta 4

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