Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice

    September 2025 in “ Physiologia
    Gabriel Siquier-Dameto, Javier Gimeno-Beltrán, Gilberto Bellia, Pere Boadas‐Vaello, Enrique Verdú
    Studysummary This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.
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