Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice

    September 2025 in “ Physiologia ”
    Gabriel Siquier-Dameto, Javier Gimeno-Beltrán, Gilberto Bellia … Enrique Verdú
    Studysummary This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 3

    1. Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration Experimental Dermatology · 2022
    2. Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System Methods in molecular biology · 2010
    3. Neurotrophins, Nociceptors, And Pain Microscopy Research and Technique · 1999