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This study found that dutasteride reduced β-amyloid plaque load in a cerebral amyloidosis model, seemingly linked to mitochondrial apoptosis and autophagy processes.

This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.

This review discusses various environmental pollutants and their potential role in promoting mitochondrial dysfunction, which may contribute to aging-related diseases, cancer, and other adverse health outcomes, but reports no new experimental results.

This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.

This review examines the role of androgens and androgen receptors in regulating glucose and lipid metabolism, focusing on their effects on mitochondrial content and function; it also discusses the sex-dimorphic influence of androgens and provides theoretical insights into their mechanisms.

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.

This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.

This source critically examines Bruce Ames's influential contributions to biochemistry, particularly his theories on oxidative stress and mitochondrial DNA damage in aging, while acknowledging current challenges to his work and highlighting his lasting impact on the fields of mutagen screening and public health.

This study suggests that cedrol may improve mitochondrial function, gut microbiota, and intestinal barrier integrity, indicating its potential value in treating inflammatory bowel disease.

This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.

This study found that cyclosporine A's enhancement of hair growth in mice is partly due to its ability to block the nuclear translocation of apoptosis-inducing factor, slowing the hair follicle transition to the catagen phase.

This study found that the PPAR-γ modulator N-acetyl-GED may enhance mitochondrial function in human hair follicles, particularly in outer root sheath keratinocytes.

This study investigated how the antioxidant MitoQ and the enzyme CYP19A1 influence mitochondrial function in androgenetic alopecia. In a mouse model, both CYP19A1 overexpression and MitoQ treatment improved mitochondrial health and reversed DHT-induced hair loss factors, suggesting potential therapeutic targets for this condition.

Applying pseudoceramide improved skin and hair health.

This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.

In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

In this study, Dguok deficiency in mice led to premature hair greying due to a loss of melanocyte stem cells and mature melanocytes, with increased oxidative stress and cell death; treatment with an antioxidant mitigated these effects, suggesting DGUOK's importance in hair pigmentation maintenance.

This review highlights the critical role of mitochondrial dysfunction in hair loss, particularly androgenetic alopecia, and explores potential therapies targeting mitochondrial pathways to improve hair health, underscoring the need for further research in this area.

In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.

This study found that β-sitosterol, a brain-penetrable phytosterol, reduced melanoma cell growth and brain metastasis formation by interfering with mitochondrial respiration, suggesting its potential as an adjuvant therapy to BRAF inhibitors for patients with melanoma brain metastases.

This study found that platelet-derived mitochondria can promote wound healing by reducing oxidative stress-induced apoptosis in vascular endothelial cells, with survivin identified as a potential target.

This review explores how androgen administration might help alleviate inflammation and mitochondrial impairment in traumatic brain injury but reports no new experimental findings, calling attention to the need for further investigation.

In this study, researchers analyzed spaceflight data from various sources and found that skin issues during spaceflight are linked to DNA damage, mitochondrial dysregulation, and gene alterations, while also highlighting the skin's adaptability post-flight.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This study found that the protein OsUEV1B is essential for maintaining phosphate balance in rice, with Pi deficiency leading to its inhibition and causing overaccumulation of phosphate in mutants.

This study found that epidermolysis bullosa simplex keratinocytes had impaired mitochondrial activity and more dispersed mitochondrial distribution compared to normal human keratinocytes.

In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.