Peroxisome Proliferator-Activated Receptors-Mediated Diabetic Wound Healing Regulates Endothelial Cells’ Mitochondrial Function Via Sonic Hedgehog Signaling

The study explores the role of peroxisome proliferator-activated receptors (PPARs) in diabetic wound healing, emphasizing their regulation of endothelial cells' mitochondrial function via the sonic hedgehog signaling pathway. It demonstrates that PPAR activation enhances mitochondrial function, angiogenesis, and endothelial cell performance, which are crucial for effective wound healing in diabetic patients. The research, involving both in vitro and in vivo experiments with diabetic mice, shows that PPAR agonists like chiglitazar improve wound healing, collagen deposition, and vascular remodeling. These findings suggest that targeting PPARs and the sonic hedgehog pathway could be a promising therapeutic strategy for diabetic foot ulcer treatment, warranting further investigation in large-scale clinical trials.