The Role of Glucose Metabolism in Wound Healing: An Overview
January 2025
in “
Burns & Trauma
”
TLDR Glucose metabolism is crucial for wound healing but can delay healing in chronic wounds due to increased stress and inflammation.
Glucose metabolism is crucial for wound healing, providing energy and supporting cell functions through glycolysis and the tricarboxylic acid cycle. It influences all stages of healing, from cell proliferation and migration to immune responses and tissue repair. Abnormal glucose metabolism, especially in chronic wounds like diabetic ulcers, can delay healing due to increased oxidative stress and inflammation. Key enzymes and glucose transporters, such as GLUT1 and GLUT3, play significant roles in this process. Targeting metabolic pathways, including lactate metabolism and signaling pathways like PI3K/AKT/mTOR and AMPK, offers potential therapeutic strategies. Understanding these pathways could lead to improved treatments for chronic wounds, emphasizing the need for further research to optimize wound healing strategies.
