Glucose-Activated Nanoreactor Initiating Cascade Reaction to Remodel Immune Microenvironment for Promoting Diabetic Wound Healing

    March 2026 in “ ACS Applied Materials & Interfaces ”
    Luoyu Zhang, Bihua Liang, Chao Bi, Quan Chen, Runxiang Li, Huiyan Deng, Liqian Peng, Jiaoquan Chen, S. Ou, Ziyan Chen, Xiaofeng Li, Huilan Zhu, Huaping Li
    TLDR MCP@G improves diabetic wound healing by reducing stress and promoting tissue repair.
    The study presents an innovative nanozyme system, MCP@G, designed to improve diabetic wound healing by remodeling the immune microenvironment. This system integrates glucose oxidase with a Pt-deposited Mn-doped Ce metal–organic framework, mimicking superoxide dismutase and catalase activities. MCP@G initiates a cascade reaction that reduces hyperglycemia, alleviates oxidative stress, and enhances oxygen supply, effectively breaking the cycle of hyperglycemia, hypoxia, and oxidative stress. In vitro and in vivo experiments, including a diabetic rat model, showed that MCP@G significantly reduced mitochondrial oxidative stress, modulated anti-inflammatory factors, enhanced fibroblast migration, and promoted blood vessel formation, leading to accelerated wound closure, robust collagen deposition, and significant hair follicle regeneration. This multienzyme mimicking strategy offers a promising platform for treating refractory diabetic wounds.
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