Zinc-Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post-Pancreatectomy Cutaneous Wound Healing
July 2025
in “
Advanced Materials
”
New to catalase? There is a guide in the encyclopedia. Read the guide → Studysummary This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.
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The study introduces a zinc-coordinated trienzyme nanogel (Zn@nGSC) designed to enhance wound healing after pancreatectomy by addressing complications such as hyperglycemia, oxidative stress, and infection. The Zn@nGSC system, which includes glucose oxidase, superoxide dismutase, and catalase, effectively modulates the wound microenvironment by reducing reactive oxygen species, lowering glucose levels, and enhancing oxygenation. Tested in a murine model, the nanogel demonstrated significant antibacterial properties, improved enzyme stability, and promoted tissue regeneration through enhanced collagen deposition, neovascularization, and immune modulation. The study highlights Zn@nGSC's potential as a multifunctional therapeutic platform for managing complex postoperative wounds, offering advantages over conventional therapies by providing sustained enzyme activity and stability under stress conditions.
