Assessment of Efficacy and Safety of Dapsone Gel 5% in the Treatment of Acne Vulgaris

The document from October 31, 2019, titled "Assessment of efficacy and safety of dapsone gel 5% in the treatment of acne vulgaris" discussed the role of hormones in the pathophysiology of acne. The study highlighted that acne vulgaris is a common skin disease affecting more than 85% of adolescents and often continuing into adulthood. The pathogenesis of acne was traditionally thought to involve excess sebum production, abnormal follicular hyperkeratinization, overgrowth of Propionibacterium acnes, and inflammation. The study also emphasized the role of androgens, particularly the enzyme 5a-reductase type 1, which is responsible for the conversion of testosterone to the more potent androgen, dihydrotestosterone (DHT). DHT was thought to mediate androgen-dependent skin diseases such as acne, hirsutism, and androgenetic alopecia. It was hypothesized that those with acne might have more active 5a-reductase type 1.