Salicylate Induces Epithelial Actin Reorganization via Activation of the AMP-Activated Protein Kinase and Promotes Wound Healing and Contraction in Mice

    July 2024 in “ Scientific Reports ”
    Kento Takaya, Keisuke Okabe, Shigeki Sakai … Kazuo Kishi
    Studysummary This study reported that administering salicylates to wounds in adult mice promoted wound healing patterns similar to embryonic wounds, enabling complete wound regeneration and reduced scarring by activating AMPK and subsequent signaling pathways.
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    Research cited in this study 3

    1. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    2. Actin cable formation and epidermis–dermis positional relationship during complete skin regeneration Scientific Reports · 2022
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018