Transcutaneous Electrical Acustimulation Promotes Wound Healing in Mice by Modulating Signaling Molecules and Mitochondria Function

The study investigates the effects of transcutaneous electrical acustimulation (TEA) on wound healing in mice, focusing on its impact on signaling molecules and mitochondrial function. The research involved three groups of mice, including a TEA treatment group, and utilized various techniques such as Western blotting and qPCR to assess protein and RNA expression levels. Results showed that TEA promotes wound healing by enhancing the expression of proteins like Wnt3a, TGF-β, Akt, and others, while also modulating mitochondrial dynamics and stress recovery responses. TEA exhibited anti-inflammatory properties, upregulated beneficial proteins, and influenced the expression of IL-10 and miRNA205-5p, while inhibiting MMP9 levels, suggesting its potential as a therapeutic approach for wound repair.