Inhibition of Mitochondrial Respiration Prevents BRAF-Mutant Melanoma Brain Metastasis

    April 2019 in “ Acta neuropathologica communications ”
    Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje … Frits Thorsen
    Studysummary This study found that β-sitosterol, a brain-penetrable phytosterol, reduced melanoma cell growth and brain metastasis formation by interfering with mitochondrial respiration, suggesting its potential as an adjuvant therapy to BRAF inhibitors for patients with melanoma brain metastases.
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    Research cited in this study 1

    1. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002