MitoQ Upregulates CYP19A1 to Protect Dermal Papilla Cells from DHT-Induced Mitochondrial Dysfunction and Apoptosis in Androgenetic Alopecia

    January 2026 in “ Biochemical Pharmacology ”
    Yujie Li, Tingru Dong, Jiamin Wu … Cuiping Guan
    Studysummary This study investigated how the antioxidant MitoQ and the enzyme CYP19A1 influence mitochondrial function in androgenetic alopecia. In a mouse model, both CYP19A1 overexpression and MitoQ treatment improved mitochondrial health and reversed DHT-induced hair loss factors, suggesting potential therapeutic targets for this condition.
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    Research cited in this study 13

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    2. The Regulatory Mechanisms of Mitophagy and Oxidative Stress in Androgenetic Alopecia Cellular Signalling · 2025
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    10. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    11. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
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