The Legacy of Bruce Ames and Mitochondrial DNA Mutagenicity: Integrating Oxidative Stress, Aging, and Modern Perspectives
October 2025
in “
Frontiers in Molecular Biosciences
”
TLDR Bruce Ames's work has greatly influenced research on genetics, aging, and health, inspiring ongoing studies on mitochondria and longevity.
Bruce Ames's contributions to genetics, toxicology, and aging research have been transformative, particularly through the development of the Ames test for detecting mutagenic chemicals and his theories on oxidative stress and mitochondrial DNA mutagenicity. While his ideas on mtDNA mutations as primary aging drivers face modern scrutiny, his work has inspired continued exploration into mitochondrial function and its impact on health and aging. Ames's legacy is his holistic approach to using mechanistic science to improve health and longevity.
