Serenoa Repens and N-Acetyl Glucosamine/Milk Proteins Complex Differentially Affect the Paracrine Communication Between Endothelial and Follicle Dermal Papilla Cells

The study explored the impact of Serenoa repens (SR) and N-acetyl glucosamine/milk proteins complex (NAG/Lac) on the interaction between endothelial cells and hair follicle dermal papilla cells. It found that SR and NAG/Lac both enhanced endothelial tubulogenesis and VEGF production, with SR having a stronger effect. SR also promoted cell proliferation, modified the expression of 5-α-reductase-II and ß-catenin in dermal papilla cells, and protected against lipid peroxidation and oxidative stress. NAG/Lac specifically increased endothelial cell proliferation and affected interleukin production. Both compounds altered endothelial permeability and tight junction protein content. The study suggests that SR and NAG/Lac have potential as treatments for hair growth and hair loss, but further research is needed to fully understand their mechanisms and effectiveness. The number of participants or samples used in the study was not mentioned.