February 2024 in “Current Medicinal Chemistry” In this study, minoxidil nanoparticles significantly increased hair growth rate in C57BL/6 mice compared to traditional minoxidil, suggesting enhanced effectiveness and potential as a new formulation.
17 citations
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April 2022 in “Bioactive Materials” This review discusses the current techniques for engineering microtissues, emphasizing the potential of continuous microfluidic processes to facilitate large-scale production, but reports no new experimental results.
January 2015 in “Journal of cosmetology & trichology” In this pilot study, eyebrow mesotherapy was reported to achieve clinically apparent thickening and darkening of eyebrows, with 8 out of 12 patients satisfied with the results after 15 days.
26 citations
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June 2011 in “International Journal of Pharmaceutics” This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.
December 2024 in “Brazilian Journal of Development” This study evaluated the quality of 5% Minoxidil samples and found that only one out of three magistral formulations met acceptance criteria, highlighting the need for stricter quality control in custom pharmacy preparations to ensure their therapeutic efficacy.
December 2023 in “International journal of high dilution research” The study reported that mice receiving dynamized Melatonin 6 cH and Lissotriton 6 cH for 14 days exhibited improved coat health and increased endurance in forced swimming tests, with Melatonin-treated mice swimming 2.5 times longer and Lissotriton-treated mice 4 times longer than controls.
3 citations
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September 2022 in “Journal of Drug Delivery Science and Technology” This study reported that encapsulating minoxidil in transferosomes and transethosomes can enhance skin permeability and drug retention compared to its conventional formulation, potentially increasing efficacy in androgenic alopecia treatment while reducing side effects, especially when transethosomes contain oleic acid.
45 citations
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January 2022 in “Lab on a Chip” This study demonstrates that a 3D-printed agarose microwell platform supports the growth of size-uniform, viable NSCLC cancer spheroids, and can effectively evaluate drug responses using limited tumor material from biopsies, particularly with EGFR tyrosine kinase inhibitors gefitinib and osimertinib.
13 citations
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February 2020 in “Journal of the American Academy of Dermatology” This study found that both oral tranexamic acid and microneedling improve melasma treatment outcomes when added to standard therapy, with microneedling showing a more sustained remission.
33 citations
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October 2016 in “European Journal of Pharmaceutical Sciences” This study found that a novel effervescent formulation significantly increased minoxidil sulphate accumulation in hair follicles and skin compared to a standard minoxidil solution.
4 citations
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March 2020 in “Scientific Reports” This study reported that polymeric nanofibers containing minoxidil sulphate showed effective encapsulation and stability, with minimal concentration loss over six months, making them potentially ideal for delivering this unstable drug in a more visually appealing and easier-to-apply form.
January 2023 in “International Journal of Molecular Sciences” This study found that a double-crosslinked hydrogel using GelMA and sulfhydrylated chitosan showed promising results in healing full-thickness skin wounds in rats by accelerating tissue repair and promoting collagen and blood vessel formation.
26 citations
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July 2021 in “Frontiers in Cell and Developmental Biology” This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
July 2024 in “Pharmaceutical Development and Technology” This study explores the potential of rosemary oil for stimulating hair growth, focusing on developing ROS-loaded microsponges to enhance its permeability for topical application, but results are not reported.
April 2023 in “International Journal of Pharmaceutics” In this study, melatonin-loaded Pickering emulsions stabilized by chitosan-dextran sulphate nanoparticles and enhanced with lecithin showed improved photostability, antioxidant activity, and follicular delivery in androgenic alopecia-affected rats, potentially rivaling commercial minoxidil for hair loss treatment.
1 citations
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December 2025 in “Stem Cell Research & Therapy” This study found that hucMSC-EXOs delivered via intratympanic injection effectively target vestibular sensory tissues, significantly reducing gentamicin-induced balance issues and high-frequency hearing loss, with some measured outcomes surpassing those achieved with dexamethasone.
This observational study found that mesotherapy with neonatal mesenchymal stem cells led to mild hair growth improvement in 70% of patients with androgenetic alopecia, with no major adverse events reported.
This study suggests that using cell-free dexamethasone-primed stem cell media may offer a promising alternative treatment for systemic lupus erythematosus, showing immunomodulatory benefits and therapeutic efficacy in reducing various complications.
66 citations
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February 2010 in “CrystEngComm” Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
May 2026 in “Nature Communications” In this study, a self-adaptive nanozyme embedded in a madecassoside-enriched hydrogel demonstrated strong antibacterial efficacy and accelerated healing in wounds infected with drug-resistant bacteria, as evidenced by improved repair and regeneration in MRSA-infected mice and preclinical pig models.
September 2025 in “Institutional Repositories DataBase (IRDB)” The nanoemulsion system effectively delivers drugs through the skin and shows promise for treating skin conditions.
December 2009 in “Eclética Química” This study developed a new permanganometric method for determining minoxidil in pharmaceutical formulations, offering a simple and rapid alternative to chromatographic procedures with recovery rates between 94.5% and 95.2%.
28 citations
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November 2013 in “The FASEB journal” In this study, a low-methionine diet significantly improved the health and physical traits of cystathionine β-synthase-deficient mice, contrasting with negative effects on mice with partial deficiency.
December 2023 in “International Journal of Biological Macromolecules” This study found that MCS nanoparticles improved Minoxidil's hair growth effects in an animal model compared to the commercial formulation, but they were less effective than CS nanoparticles despite showing better solubility with minimal side effects.
39 citations
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April 2022 in “Biomedical Materials” In this study, a biofunctional hydrogel incorporating mesenchymal stem cell-derived small extracellular vesicles promoted wound healing and reduced scar tissue formation by modulating the immune response in a mouse skin injury model.
29 citations
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December 2021 in “Biomedicines” This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.
June 2024 in “BioSCIENCE” This study reviewed the use of microinfusion of microparticles (MMP®) with methotrexate for treating alopecia frontal fibrosante and found it reduced symptoms associated with the condition and improved specific scalp measurements, showing that the technique is safe and well-tolerated.
46 citations
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January 2008 in “Journal of cosmetic dermatology” Caffeine and siloxanetriol alginate caffeine in emulsion form can reduce fatty cell size and number, potentially treating cellulite effectively.
January 2024 in “Biological Research” This study found that mesenchymal stem cell-derived exosomes reduced hearing and hair cell loss caused by neomycin in experimental models by modulating autophagy, which promoted cell survival and lowered oxidative stress and apoptosis, indicating potential for deafness treatment.
4 citations
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October 2022 in “Journal of Biomedical Materials Research Part A” This study found that magnesium oxide-incorporated electrospun membranes improved wound healing in a simulated model by accelerating wound closure, reducing inflammation, promoting fibroblast proliferation, and stimulating angiogenesis and skin regeneration.