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research ‘Malignant melanoma microecosystem’: Immunohistopathological insights into the stromal cell phenotype
This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.
research Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
This case report highlights that equine multisystemic eosinophilic epitheliotropic disease should be considered in horses presenting with skin lesions and gastrointestinal symptoms, as illustrated by the progression in a 5-year-old horse despite treatment.
research Ethosome: a novel vesicular carrier for transdermal drug delivery
This article reviewed the preparation, application, and characterization of ethosomes as drug delivery transporters and reported that in a double-blind randomized clinical study, ethosomal acyclovir significantly improved all evaluated parameters in skin delivery, highlighting potential for novel therapies.
research Repeatable Perming via Thiol–Michael Click Reaction: Using Amide Derived from Maleic Acid and Cystine
In this study, the novel thiol-Michael click perming molecule, MA2-CySS, achieved repeatable perming with reduced oxidative damage, preserving hair keratin's structure while maintaining efficiency comparable to traditional oxidative methods.
research Potential of polar lipids from bovine milk to regulate the rodent dorsal hair cycle
This study found that topical application of bovine milk polar lipids accelerated hair cycle progression in mice, showing potential for use in cosmetic products.
research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen
This article describes the efficient synthesis of (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide, a novel topical antiandrogen, with high purity and enantiomeric excess but reports no pharmacological results.
research Lipid nanocosmeceuticals: a novel approach to skin therapy for anti-aging and skin disorders
This study reviews lipid-based nanocosmeceuticals and reports that they enhance therapeutic effectiveness in dermatological applications by improving skin hydration, reducing wrinkles, and effectively managing conditions like psoriasis and eczema, though further large-scale trials and regulatory alignment are needed for clinical use.
research Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment
This review discusses the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles for chronic wound treatment and reports no new clinical results, emphasizing the need for further research on their large-scale production and engineering.
research Development and In Vitro Characterization of Neusilin® US2-Based Solid Self-Nanoemulsifying Drug Delivery System for Oral Administration of Finasteride
This study developed a Neusilin® US2-based solid self-nanoemulsifying drug delivery system for finasteride that showed improved stability and drug delivery, with complete dissolution comparable to standard Propecia® tablets.
research Spanlastic Nano-Vesicles: A Novel Approach to Improve the Dissolution, Bioavailability, and Pharmacokinetic Behavior of Famotidine
This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.
research Expert consensus on the clinical application of Tianmeng oral liquid in psychosomatic disorders
This review, sourced from expert panel discussions and literature analysis, suggests Tianmeng oral liquid may improve sleep, reduce anxiety and depression, and enhance well-being in psychosomatic disorder patients, though further research is necessary.
research SUCCESSFUL 28-DAY COMBINATION THERAPY OF MALASSEZIA DERMATITIS IN A 1-YEAR-OLD MIXED SMALL-BREED DOG: A CASE REPORT
In this case report, combination therapy effectively resolved chronic malasseziosis within 28 days in a small-breed dog from a Southeast Asian tropical climate, with significant symptom improvement and reduced Malassezia density observed by week 4.
research Sky Fruit Seed Crush (SFSC): A potential Source of less Salt Curing of Raw Goatskin
In this study, utilizing a mixture of crushed sky fruit seeds and sodium salt for goat skin preservation led to a significant reduction in environmental impact, decreasing total dissolved solids by 59% and chloride content by 44%, while maintaining the physical quality of processed leather.
research Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation
In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.
research Minoxidil-Coated Lysozyme-Shelled Microbubbes Combined With Ultrasound for the Enhancement of Hair Follicle Growth: Efficacy In Vitro and In Vivo
In this mouse study, the combination of minoxidil-coated lysozyme microbubbles and ultrasound significantly enhanced hair growth compared to minoxidil alone.
research Murine skin as a target for melatonin bioregulation
This study found that murine skin is a target for melatonin bioregulation, as melatonin affected DNA synthesis and tyrosinase activity in skin organ culture.
research Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment
This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.
research Lymphatic remodeling and metabolic rescue by VEGFR-3/DHA-coordinated microneedles for hair regeneration
This study developed a dissolvable microneedle system delivering specific molecules to remodel lymphatic networks and normalize metabolic processes, which accelerated hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia.
research Cholesterol and Phospholipid-free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administrated for Treating Diseases in Deep Hair Follicles
This study found that cholesterol- and phospholipid-free multilamellar niosomes improved skin deposition and targeted deeper hair follicles better than hydrophobic PLGA nanoparticles for transdermal drug delivery.
research Polyphenol-mediated biomimetic mineralization of sacrificial metal-organic framework nanoparticles for wound healing
This study developed a novel mineralization strategy using metal-polyphenol coordination for dynamic control of nano-scale processes, enhancing hydrogels that support wound healing with antibacterial and angiogenesis-promoting properties.
research Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series
In this case series, mesenchymal stem cell exosomes were reported to improve hair length, density, pigmentation, and cuticle layer recovery in three patients with acquired trichorrhexis nodosa, suggesting potential as a therapeutic approach for this hair condition.
research Development and Optimization of Finasteride-Cinnamon Oil-Loaded Ethanol-Free Microemulsions for Transdermal Delivery
In this study, researchers developed and optimized ethanol-free microemulsion systems for transdermal finasteride delivery, finding that the predicted formulations closely matched their physical and chemical characteristics, potentially reducing adverse effects compared to oral administration.
research Dissolving microneedles incorporating kopexil multicomponent crystals for improved transdermal delivery
This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
research Dermal drug delivery with ethosomes: therapeutic potential
This review discusses ethosomes as potential carriers for delivering drugs into deeper skin layers and provides no new clinical results, suggesting a need for further studies on their efficiency in dermal therapies.
research Determination of Minoxidil by Bleaching the Permanganate Carrier Solution in a Flow-Based Spectrophotometric System
This study demonstrated that a flow injection method using potassium permanganate for detecting minoxidil provided accurate recoveries and agreed closely with HPLC results, showing potential for effective analysis of commercial samples.
research Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: A novel methods for hair follicle mesenchymal stem cells isolation.
This study reported that pelage hair follicle mesenchymal stem cells isolated from mice using Ficoll Density Gradient Sedimentation can be obtained in large numbers and may promote hair growth via exosome secretion.
research Effects of different dietary protein levels and DL‐methionine supplementation on hair growth and pelt quality in mink (Neovision vision)
This study demonstrated that mink hair growth and pelt quality significantly depend on dietary protein levels and DL-methionine supplementation during the growing-furring period.
research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells (SH-MSCs) on IL-10 and TNF- α Gene Expression (In Vivo Experimental Study in Male Rats of Wistar Strains Model of Fluconazole-Induced Alopecia)
In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.
research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis
In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.