Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen
January 2017
in “
Organic Process Research & Development
”
TLDR In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.
In 2017, researchers developed an efficient method for producing a new topical antiandrogen, (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide 1, on a kilogram scale with an overall yield of 25% and a purity of 98.8%. The process involved a key amide coupling, the use of a temporary protecting group, and a final crystallization step. The compound was designed for the treatment of excess sebum and acne. The document does not mention any study involving people or any subjects related to hair loss, alopecia, or hair growth.
