Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

    Sebastien Daver, Nicolas Rodeville, Francois Pineau, Jean-Marie Arlabosse, Christine Moureou, Franck Muller, Romain Pierre, Karinne Bouquet, Laurence Dumais, Jean-Guy Boiteau, Isabelle Cardinaud
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    Studysummary This article describes the efficient synthesis of (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide, a novel topical antiandrogen, with high purity and enantiomeric excess but reports no pharmacological results.
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