Cosmeceuticals

    June 2004
    Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth
    Image of study
    TLDR Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.
    The 2004 document discussed the properties and synthesis of four cosmeceuticals: isotretinoin, tazarotene, minoxidil, and finasteride. Isotretinoin and tazarotene are used for acne treatment, with isotretinoin reducing sebaceous gland size and sebum production, and tazarotene normalizing keratinocyte differentiation and proliferation. Minoxidil and finasteride are used for hair growth. Minoxidil was initially a vasodilator for hypertension treatment but was found to promote hair growth when applied topically. Finasteride, initially developed for benign prostatic hyperplasia (BPH), inhibits 5α-reductase, which converts testosterone to a more potent androgen, 5α-dihydrotestosterone (DHT), thus lowering DHT levels without affecting testosterone levels. A study found finasteride increased hair weight in four out of five balding monkeys and was more effective when combined with minoxidil. In clinical trials, finasteride was effective at a dose of 5 mg/day for androgenic alopecia.
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      community Minoxidil works only with Retinoic acid

      in Minoxidil  308 upvotes 6 days ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

      community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

      in Research/Science  2 upvotes 1 week ago
      Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

      community is anyone using ru58841 against acne?

      in Technology  3 upvotes 5 months ago
      RU58841 is discussed as a potential treatment for acne and hair loss, with users debating its effectiveness and safety compared to other treatments like finasteride, minoxidil, and dutasteride. Concerns about RU58841's side effects and lack of clinical trials are raised, while some users share their personal experiences and routines involving RU58841 for hair loss.

      community Isotretinoin and Tretinoin difference

      in Product  2 upvotes 8 months ago
      Isotretinoin and tretinoin are different; isotretinoin can cause hair loss and has more side effects. Tretinoin may affect minoxidil absorption, and users suggest waiting before applying minoxidil.

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