Development and Optimization of Finasteride-Cinnamon Oil-Loaded Ethanol-Free Microemulsions for Transdermal Delivery

    January 2021 in “ Social Science Research Network
    Sureewan Duangjit, Napapat Rattanachithawat, Praneet Opanasopit, Tanasait Ngawhirunpat
    TLDR The optimized microemulsion with finasteride and cinnamon oil can effectively deliver the drug through the skin without using ethanol.
    The study aimed to develop and optimize ethanol-free microemulsions (MEs) for the transdermal delivery of Finasteride (FN) to treat androgenic alopecia, minimizing systemic adverse effects. Using a hexagonal lattice design and Design Expert® software, the researchers formulated an FN-loaded ME with cinnamon oil, Tween®20, propylene glycol, and water. The optimal ME contained 11.58% cinnamon oil, 58.42% surfactant mixture, and 30% water. The physicochemical properties closely matched the predicted values, and scanning electron microscopy showed no significant damage to hair fibers treated with the ME. The study successfully predicted optimal ethanol-free ME systems for FN transdermal delivery.
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