Determination of Minoxidil by Bleaching the Permanganate Carrier Solution in a Flow-Based Spectrophotometric System
January 2011
in “
Analytical Letters
”
TLDR The method quickly and accurately measures minoxidil in drugs, comparable to standard techniques.
The study presented a flow injection analysis (FIA) spectrophotometric system for determining minoxidil (MX) in pharmaceutical formulations, using potassium permanganate as a carrier. The method demonstrated a linear detection range for MX from 1.0 × 10^-5 to 5.0 × 10^-4 mol L^-1 and a limit of detection of 8.92 × 10^-6 mol L^-1. It allowed for 32 determinations per hour and showed recoveries between 104.7% and 106.4% when applied to commercial samples. The results were comparable to high-performance liquid chromatography (HPLC), with relative errors between 0.48% and 1.4% and agreement within a 95% confidence level. The method was optimized for temperature and other parameters, with the best results at 50°C, offering a fast, reliable, and cost-effective alternative for MX determination.
