Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography

January 1983 in “ Analyst ”

Lawrence N. Amankwa, L.G. Chatten, Stanley Pons

minoxidil differential-pulse polarography methanol polarographic cell sulphuric acid Britton-Robinson buffer Rogaine

TLDR Method measures minoxidil in tablets accurately and easily.

The paper presents a method for determining the concentration of minoxidil in pharmaceutical tablets using differential-pulse polarography. The method involves extracting minoxidil from the tablets using methanol and then using a polarographic cell with 1.0 N sulphuric acid as the supporting electrolyte to determine the concentration of minoxidil. The method was found to be sensitive, accurate, and easy to perform for routine analysis. The study also investigated the electrochemical properties of minoxidil and its determination in tablets by differential-pulse polarography. Minoxidil was found to exhibit two polarographic waves in 1.0 N sulphuric acid and in Britton-Robinson buffer. The proposed method for determining minoxidil in tablets has the advantages of simplicity, high sensitivity, and rapidity.

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