Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples

    January 2009 in “ Eclética Química ”
    Rogério Adelino de Sousa, Éder Tadeu Gomes Cavalheiro
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    TLDR Scientists developed a cheaper, but slower, method to measure minoxidil in hair loss treatments with high accuracy.
    In 2009, researchers developed a potentiometric titration method to measure minoxidil in commercial topical pharmaceuticals, using a redox reaction with potassium dichromate in sulfuric acid at 60°C. The method, which had minoxidil and potassium dichromate concentrations of 1.00 x 10^-2 mol L^-1 and 1.00 x 10^-3 mol L^-1 respectively, was applied to Regaine® and Neoxidil samples, yielding recoveries between 97.4% and 98.7%. The results were comparable to chromatographic methods within a 90% confidence level, suggesting this approach as a cost-effective, albeit time-consuming, quality control option for pharmacies.
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