Modulation of Electroosmotic Flow Through Skin: Effect of Polyamidoamine Dendrimers
January 2018
in “
Biomolecules & therapeutics
”
polyamidoamine dendrimers electroosmotic flow skin acetoaminophen generation 1 dendrimers generation 4 dendrimers generation 7 dendrimers methanol confocal microscopy fluorescein isothiocyanate viable epidermis dermis hair follicle anodal current iontophoresis PAMAM dendrimers EOF G1 dendrimers G4 dendrimers G7 dendrimers FITC
TLDR Polyamidoamine dendrimers can change the strength and direction of electroosmotic flow through the skin, affecting drug delivery.
The study investigated the effect of Poly(Amidoamine) (PAMAM) dendrimers on electroosmotic flow (EOF) through skin, finding that larger dendrimers (G4 and G7) significantly decreased anodal flux and could reverse EOF direction due to their higher positive surface charges. Confocal microscopy showed that G4 dendrimers penetrated the viable epidermis and dermis, mainly through hair follicles. These findings suggested that PAMAM dendrimers could modulate EOF by interacting with charged pores in the skin, offering potential for enhanced transdermal drug delivery via iontophoresis.
