Dissolving Microneedles Incorporating Kopexil Multicomponent Crystals for Improved Transdermal Delivery

    Ying Deng, Si Nga Wong, Wing Chi Nico Chan, Xinyue Zhang, Shing Fung Chow
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    Studysummary This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
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    This study explores the use of multicomponent crystals (MCCs) in microneedle drug delivery for treating androgenetic alopecia (AGA). Researchers synthesized kopexil (KPX), a minoxidil analog, into MCCs with benzoic acid and salicylic acid, forming KPX-BA·H2O and KPX-SA·H2O hydrates. These MCCs were incorporated into dissolving microneedles, which showed improved transdermal delivery by reducing KPX diffusion by 1.86-fold and 3.20-fold compared to KPX·H2O in vitro. The study highlights the potential of MCCs for enhancing drug delivery, offering a promising strategy for clinical application in AGA treatment due to their biocompatibility, scalable production, and painless application.
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