benzoic acid
Research
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research Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2
In this study, 4-(4-(phenylaminocarbonyl)benzoyl) benzoic acid exhibited the strongest inhibitory activity against the human type 2 steroid 5α-reductase isozyme among the compounds tested.
research Prooxidant And Antioxidant Action Of 4-(4-Phenoxybenzoyl)benzoic Acid Derivatives
This study found that 4-(4-Phenoxybenzoyl)benzoic acid derivatives may act as antioxidants by scavenging certain reactive oxygen species but exhibit prooxidant behavior under specific conditions.
research Dissolving Microneedles Incorporating Kopexil Multicomponent Crystals for Improved Transdermal Delivery
This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
research Novel 5α-Reductase Inhibitors: Synthesis, Structure-Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids
In this study, novel substituted benzoyl benzoic acids and phenylacetic acids were potent and selective inhibitors of human steroid 5alpha-reductase type 2, with one compound showing promising bioavailability in rats for potential clinical evaluation.
research Ketoconazole-P Aminobenzoic Cocrystal Exhibits a Potent Anti-Inflammatory Effect on the Skin of BALB/c Mice
This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.
research Changes in the Serum Metabolomics of Polycystic Ovary Syndrome Before and After Compound Oral Contraceptive Treatment
In this study, COC treatment led to greater improvements in sex hormone, endocrine factor, and metabolic levels among PCOS patients compared to those who did not receive the treatment.
research Attempted Construction of Minoxidil: Carboxylic Acid Cocrystals; 7 Salts and 1 Cocrystal Resulted
Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
research Caffeic Acid Skin Absorption: Delivery of Microparticles to Hair Follicles
This study reported that microparticle-loaded emulsions containing caffeic acid achieved more homogeneous distribution and prolonged release in hair follicles, suggesting potential for effective folliculitis treatment.
research Anti-Hair Loss Effect of Veratric Acid on Dermal Papilla Cells
Veratric Acid may help promote hair growth and reduce hair loss.
![Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions](/images/assets/2aedba8c-b0ac-4fa3-9ac7-9f375a016bba/small/15581.jpg)
research Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions
This study explored how modifying the 8-substituent of 8-bromobenzoquinolinone affects its selectivity in inhibiting both 5 alpha-reductase isozymes in the scalp.
research Phytochemicals And Pharmacological Properties Of Nyctanthes Arbor-Tristis: A Review
This review highlights that Nyctanthes arbor-tristis contains numerous phytochemicals and has traditional uses for various conditions. It also reports pharmacological activities, suggesting potential benefits for diabetes, cancer, inflammation, and more.
research Ethnopharmacological Significance of Eclipta Alba (L.) Hassk. (Asteraceae)
This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.
research In Silico Prediction of Prostaglandin D2 Synthase Inhibitors from Herbal Constituents for the Treatment of Hair Loss
This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.
research Resveratrol Derivatives: A Patent Review (2009–2012)
This review discusses various resveratrol derivative patents for therapeutic, nutraceutical, and cosmetic use, but reports no clinical results and notes that claims of improved efficacy lack trial evidence.
research Alopecia: The Search for Novel Agents Continues
This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
research Phenolic Composition, Enzyme Inhibitory, and Antioxidant Activity of Bituminaria Bituminosa
This study found that the water extract of Bituminaria bituminosa demonstrated the highest antioxidant activity and α-glucosidase inhibition among tested extracts, but no cholinesterase or tyrosinase inhibition.
research The Scientific Legacy of Stephen Rothman
This review highlights Stephen Rothman's influential role in transforming dermatology into a rigorous scientific discipline but does not report new clinical research outcomes.
research Extraction of Gallic Acid and Ferulic Acid for Application in Hair Supplements
This study successfully extracted gallic acid and ferulic acid using a biocompatible aqueous two-phase system, suggesting a sustainable approach for producing antioxidants as food supplements for hair health.
research Dermatological Medications and Local Therapeutics During Pregnancy
This review discusses the safety of dermatological medications used during pregnancy, highlighting that retinoids have strong teratogenic risks and should be used with caution; it reports no new clinical results.
research Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis
Ch55 may help reduce skin scarring and fibrosis.