TLDR The MPA-ISO cocrystal improved solubility and dissolution rate, while the others did not.
Three novel cocrystals of mycophenolic acid (MPA) with isonicotinamide (MPA-ISO), minoxidil (MPA-MIN), and 2,2′-dipyridylamine (MPA-DPA) were successfully prepared using slow evaporation and liquid-assisted grinding. Structural analysis revealed that all three coformers formed hydrogen bonds with the carboxylic acid group of MPA. The MPA-ISO cocrystal exhibited a 30% increase in solubility compared to pure MPA, while the other two cocrystals showed decreased solubility. All cocrystals remained stable in phosphate buffer (pH 6.8) after 24 hours.
166 citations,
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