Kopexil vs Minoxidil: In Vivo Comparative Study on Hair Growth, Hair Growth Promoting Factors and Toxicity

August 2024 in “ Bioimpacts ”

Sina Jalilzadeh, Nariman Maroofpour, Farnaz Monajjemzadeh

kopexil minoxidil hair growth hair growth promoting factors HGF VEGF anagen hair follicle count toxicity tests liver weights kidney weights morphology 5% hydro-alcoholic solution Rogaine

From the encyclopedia

Kopexil →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Vascular Endothelial Growth Factor →

Studysummary In this study on mice, a hydro-alcoholic solution containing kopexil significantly enhanced hair growth and increased hair-promoting factors without causing notable liver or kidney toxicity compared to minoxidil. Our plain-language summary of this paper — not a Tressless recommendation.

This study compared the effects of a 5% hydro-alcoholic solution containing kopexil to minoxidil on hair growth in mice over 28 days. The kopexil group showed significant improvements in hair weight, follicle count, percentage of anagen hair, and overall hair growth compared to the minoxidil group. Western blot analysis indicated higher levels of hair growth-promoting factors (HGF and VEGF) in the kopexil-treated group. Toxicity tests revealed no significant differences in liver and kidney weights or morphological changes among the groups. The findings suggest that kopexil is an effective and safe hair growth stimulator, making it a viable treatment option for hair loss.

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Research cited in this study

27 / 27 results

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