Cholesterol and Phospholipid-Free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administered for Treating Diseases in Deep Hair Follicles

    August 2021 in “ Journal of Pharmaceutical Sciences ”
    Tong Wu, Chunyun Zhu, Xiang Wang … Nianping Feng
    Studysummary This study found that cholesterol- and phospholipid-free multilamellar niosomes improved skin deposition and targeted deeper hair follicles better than hydrophobic PLGA nanoparticles for transdermal drug delivery.
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    Research cited in this study 11

    1. Hair Growth Promoting Effect of Bioactive Extract from Deer Antler Velvet-Loaded Niosomes and Microspicules Serum International Journal of Pharmaceutics · 2021
    2. Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers Pharmaceutical Research · 2020
    3. Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice International Journal of Nanomedicine · 2019
    4. Do Nanoparticles Have a Future in Dermal Drug Delivery? Journal of Controlled Release · 2016
    5. Transfollicular Enhancement of Methyl Myristate Loaded in Cationic Niosomes Incorporated in Hair Lotion Journal of microencapsulation · 2016
    6. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    7. Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction European Journal of Pharmaceutics and Biopharmaceutics · 2012
    8. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    9. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    10. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    11. Liposomes and Niosomes as Topical Drug Delivery Systems Skin pharmacology and physiology · 2005