Cholesterol and Phospholipid-Free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administered for Treating Diseases in Deep Hair Follicles

August 2021 in “ Journal of Pharmaceutical Sciences ”

Tong Wu, Chunyun Zhu, Xiang Wang, Qingyue Kong, Teng Guo, Zehui He, Yuanzhi He, Shuyao Ruan, Hang Ruan, Lixia Pei, Yongtai Zhang, Nianping Feng, Tong Wu, Chunyun Zhu, Xiang Wang, Qingyue Kong, Teng Guo, Zehui He, Yuanzhi He, Shuyao Ruan, Hang Ruan, Lixia Pei, Yongtai Zhang, Nianping Feng

multilamellar niosomes glyceryl monooleate poloxamer 407 transdermal drug delivery hair follicles aconitine fibroblasts PLGA nanoparticles skin permeability

TLDR Cholesterol- and phospholipid-free niosomes improve deep skin drug delivery.

The study developed cholesterol- and phospholipid-free multilamellar niosomes (MLNs) using glyceryl monooleate and poloxamer 407 to improve transdermal drug delivery to deep hair follicles. The MLNs, with a mean size of 97.88 nm and an encapsulation efficiency of 82.68%, showed sustained release and enhanced skin permeation, achieving higher skin deposition of aconitine compared to tincture. Labeled MLNs penetrated deeply into the skin via hair follicles and were internalized by fibroblasts, offering advantages over hydrophobic PLGA nanoparticles, which mainly accumulated in superficial hair follicles. This suggested that MLNs could significantly enhance skin permeability, presenting a promising alternative for topical and transdermal drug delivery.

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