Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth in C57BL/6 Mice

    February 2024 in “ Current Medicinal Chemistry
    Ali Mashinchian Moradi, Seyed Morteza Seifati, Majid Darroudi, Shiva Golmohammadzadeh, Mahmood Dehghani Ashkezari
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    TLDR Minoxidil nanocrystals improved hair growth in mice more effectively and safely than regular Minoxidil.
    The study aimed to enhance the bioactivity and water solubility of Minoxidil (MXD), a common hair growth stimulator, by creating nanocrystal structures (MXD-NPs) and testing their effect on C57BL/6 mice. The MXD-NPs were prepared using a bead mill and ultrasonic process and were characterized using various techniques. The cytotoxicity of MXD-NPs was tested on human dermal fibroblast (HDF) cells. The results showed that the MXD-NPs significantly increased the hair growth rate in C57BL/6 mice by targeting pilosebaceous follicles more effectively than regular MXD. The mice treated with MXD-NPs showed a higher rate of anagen/telogen follicular growth compared to those treated with MXD, indicating improved hair regrowth and follicular stimulation. This suggests that MXD-NPs could potentially replace the commercial solution format of MXD as a safer and more efficient structure.
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      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  239 upvotes 3 days ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

      community Smoking minoxidil, the theory that changes everything.

      in Minoxidil  581 upvotes 4 days ago
      A user humorously suggested smoking minoxidil in a blunt as an alternative hair growth method, sparking a satirical discussion on unconventional and unsafe ways to use minoxidil. The conversation included various suggestions like oral pills, rectal administration, and other absurd methods, with some users warning against the dangers of such practices.

      community Why don't Minoxidil regenerated hairs become terminal on the head?

      in Minoxidil  100 upvotes 4 days ago
      Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

      community Be careful with minoxidil, even if it's just foam.

      in Minoxidil  12 upvotes 5 days ago
      Minoxidil caused side effects like chest pain and tinnitus for the user, leading them to stop using it and consider switching to finasteride with microneedling. Other users shared similar experiences with minoxidil, while some reported no issues, highlighting varied individual reactions.

      community 8 months on oral minoxidil. No sign of regrowth.

      in Minoxidil  14 upvotes 1 week ago
      The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

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