Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth in C57BL/6 Mice
February 2024
in “
Current Medicinal Chemistry
”
minoxidil nanocrystal structures MXD-NPs hair growth stimulator C57BL/6 mice bead mill ultrasonic process human dermal fibroblast cells pilosebaceous follicles anagen/telogen follicular growth hair regrowth follicular stimulation Rogaine nanocrystals nanoparticles hair growth mice HDF cells hair follicles hair growth phases
![Image of study](/images/research/7eb90719-4716-4e14-8fac-030d67702349/medium/26433.jpg)
TLDR Minoxidil nanocrystals improved hair growth in mice more effectively and safely than regular Minoxidil.
The study aimed to enhance the bioactivity and water solubility of Minoxidil (MXD), a common hair growth stimulator, by creating nanocrystal structures (MXD-NPs) and testing their effect on C57BL/6 mice. The MXD-NPs were prepared using a bead mill and ultrasonic process and were characterized using various techniques. The cytotoxicity of MXD-NPs was tested on human dermal fibroblast (HDF) cells. The results showed that the MXD-NPs significantly increased the hair growth rate in C57BL/6 mice by targeting pilosebaceous follicles more effectively than regular MXD. The mice treated with MXD-NPs showed a higher rate of anagen/telogen follicular growth compared to those treated with MXD, indicating improved hair regrowth and follicular stimulation. This suggests that MXD-NPs could potentially replace the commercial solution format of MXD as a safer and more efficient structure.