Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth in C57BL/6 Mice

    February 2024 in “ Current Medicinal Chemistry ”
    Ali Mashinchian Moradi, Seyed Morteza Seifati, Majid Darroudi, Shiva Golmohammadzadeh, Mahmood Dehghani Ashkezari
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    TLDR Minoxidil nanocrystals improved hair growth in mice more effectively and safely than regular Minoxidil.
    The study aimed to enhance the bioactivity and water solubility of Minoxidil (MXD), a common hair growth stimulator, by creating nanocrystal structures (MXD-NPs) and testing their effect on C57BL/6 mice. The MXD-NPs were prepared using a bead mill and ultrasonic process and were characterized using various techniques. The cytotoxicity of MXD-NPs was tested on human dermal fibroblast (HDF) cells. The results showed that the MXD-NPs significantly increased the hair growth rate in C57BL/6 mice by targeting pilosebaceous follicles more effectively than regular MXD. The mice treated with MXD-NPs showed a higher rate of anagen/telogen follicular growth compared to those treated with MXD, indicating improved hair regrowth and follicular stimulation. This suggests that MXD-NPs could potentially replace the commercial solution format of MXD as a safer and more efficient structure.
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