Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth in C57BL/6 Mice

February 2024 in “ Current Medicinal Chemistry ”

Ali Mashinchian Moradi, Seyed Morteza Seifati, Majid Darroudi, Shiva Golmohammadzadeh, Mahmood Dehghani Ashkezari

TLDR Minoxidil nanocrystals improved hair growth in mice more effectively and safely than regular Minoxidil.

The study aimed to enhance the bioactivity and water solubility of Minoxidil (MXD), a common hair growth stimulator, by creating nanocrystal structures (MXD-NPs) and testing their effect on C57BL/6 mice. The MXD-NPs were prepared using a bead mill and ultrasonic process and were characterized using various techniques. The cytotoxicity of MXD-NPs was tested on human dermal fibroblast (HDF) cells. The results showed that the MXD-NPs significantly increased the hair growth rate in C57BL/6 mice by targeting pilosebaceous follicles more effectively than regular MXD. The mice treated with MXD-NPs showed a higher rate of anagen/telogen follicular growth compared to those treated with MXD, indicating improved hair regrowth and follicular stimulation. This suggests that MXD-NPs could potentially replace the commercial solution format of MXD as a safer and more efficient structure.

View this study on eurekaselect.com →

Discuss this study in the Community →

Related Research

9 / 9 results

research Safety and Efficacy of Trimax-360 Serum in Healthy Adult Subjects with Mild to Moderate Alopecia of the Scalp

April 2022 in “Journal of Cosmetic Dermatology”

Trimax-360 Serum, when used for 98 days, safely and effectively improves hair growth, thickness, and density without any side effects.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Effectiveness of Once Daily 5% Minoxidil Topical Foam in the Treatment of Women with Thinning Hair Due to Female Pattern Hair Loss

May 2015 in “Journal of The American Academy of Dermatology”

5% minoxidil foam helps women with thinning hair.

research Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil

21 citations, January 2007 in “Australasian Journal of Dermatology”

Spironolactone and minoxidil together effectively treat female pattern hair loss.

research Androgenetic Alopecia in Adolescents

12 citations, February 2003 in “PubMed”

research Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women

1 citations, September 2002 in “PubMed”

Minoxidil helps stimulate hair growth and reduce hair loss in women with androgenic alopecia.

research Treatment of Hair Loss

370 citations, September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research Clinical Updates in Hair

19 citations, January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth in C57BL/6 Mice

Related Community Posts Join

community Advice needed, did exosomes, PRP, and Regenera treatment done, and have been consistently taking oral minoxidil (2.5mg) and finasteride (1mg) for 1 year.

community How come beard hair on minoxidil is permanent while scalp hair while on it under fin/duta is not?

community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.

community The initial Minoxidil shed is scary af, but I'm sticking to it.

community What is the best percentage of Tretinoin to add to minoxidil?

community Can Tazarotene Upregulate Minoxidil Conversion Like Tretinoin?