Mesenchymal Stem Cell-Derived Exosomes Ameliorate Gentamicin-Induced Vestibular Hair Cell Injury by Regulating the SNARE Pathway and Enhancing Autophagy
December 2025
in “
Stem Cell Research & Therapy
”
mesenchymal stem cell-derived exosomes human umbilical cord mesenchymal stem cell-derived exosomes hucMSC-EXOs SNARE pathway autophagy gentamicin-induced vestibular hair cell injury intracellular injection vestibular sensory epithelia balance dysfunction high-frequency hearing loss saccular hair cell repair dexamethasone anti-apoptosis pro-autophagy stem cell exosomes exosomes balance disorder hearing loss hair cell repair steroid
Studysummary This study found that hucMSC-EXOs delivered via intratympanic injection effectively target vestibular sensory tissues, significantly reducing gentamicin-induced balance issues and high-frequency hearing loss, with some measured outcomes surpassing those achieved with dexamethasone.
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