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    Glossary Mesenchymal Stem Cell-Derived Exosomes

    tiny vesicles from stem cells aiding tissue repair and hair growth

    Mesenchymal Stem Cell-Derived Exosomes (MSC exosomes) are tiny vesicles released by mesenchymal stem cells that contain proteins, lipids, and genetic material. These exosomes play a crucial role in cell communication and have shown potential in regenerative medicine, including promoting hair growth and treating conditions like alopecia by delivering therapeutic molecules to damaged tissues.

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    1. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    2. Exploring the Potential of Mesenchymal Stem Cell–Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021 · 12 citations
    3. Mesenchymal stem cell‐derived exosomes for organ development and cell‐free therapy Nano select · 2021 · 4 citations
    4. Mesenchymal stem cell-derived exosomes ameliorate gentamicin-induced vestibular hair cell injury by regulating the SNARE pathway and enhancing autophagy Stem Cell Research & Therapy · 2025 · 1 citations
    5. Mesenchymal Stem Cell-derived Exosomes Improved Healing of Cutaneous Wound in a Rat Model Journal of Microscopy and Ultrastructure · 2024 · 1 citations
    6. Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway Frontiers in Cell and Developmental Biology · 2026
    7. Hypoxia-Induced Mesenchymal Stem Cell-Derived Exosome Enhance TGF-β, PDGF, and Hair Growth in Alopecia-Like Rat Models Biosaintifika Journal of Biology & Biology Education · 2026
    8. Mesenchymal stem cell-derived exosomes for the treatment of skin and subcutaneous tissue diseases: current evidence from clinical trials Eurasian journal of applied biotechnology · 2025
    9. Mesenchymal Stem Cell-derived Exosomes in the Treatment of Skin and Subcutaneous Tissue Diseases: A Review Current Stem Cell Research & Therapy · 2025
    10. Mesenchymal Stem Cell-Derived Exosomes Can Effectively Improve the Hair Count and Terminal Hair Diameter in Androgenetic Alopecia Research Square (Research Square) · 2025
    11. Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes Theranostics · 2025
    12. Potential of mesenchymal stem cell-derived exosomes in the treatment of androgenetic alopecia World Journal of Stem Cells · 2025
    13. EXPLORING THE EFFICACY AND THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELL–DERIVED EXOSOMES FOR THE TREATMENT OF ANDROGENIC ALOPECIA 2024
    14. Regenerative potential and clinical application of mesenchymal stem cell-derived exosomes (review) Klìtinna ta organna transplantologìâ · 2023
    15. Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia Molecular and Cellular Biomedical Sciences · 2026
    16. Adipose Mesenchymal Stem Cell‐Derived Exosomes Versus Platelet‐Rich Plasma Treatment for Photoaged Facial Skin: An Investigator‐Blinded, Split‐Face, Non‐Inferiority Trial Journal of Cosmetic Dermatology · 2025 · 13 citations
    17. Chitosan Hydrogel Dressing Loaded with Adipose Mesenchymal Stem Cell-Derived Exosomes Promotes Skin Full-Thickness Wound Repair ACS applied bio materials · 2024 · 1 citations
    18. Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2– ARE Pathway in C57BL / 6J Mice Journal of Cosmetic Dermatology · 2026
    19. Hypoxia Mesenchymal Stem Cell-Derived Exosomes (EH-MSCs) enhance IGF-1 and suppress IL-1Beta in hair follicle regeneration DOAJ (DOAJ: Directory of Open Access Journals) · 2026
    20. Thrombin-preconditioned Mesenchymal Stem Cell-Derived Exosomes For Wound Healing in vitro and in vivo bioRxiv (Cold Spring Harbor Laboratory) · 2025
    21. Human hair follicle mesenchymal stem cell-derived exosome attenuates UVB-induced photoaging via the miR-125b-5p/TGF-β1/Smad axis Biomaterials Research · 2024
    22. Efficacy of Placental-Derived Mesenchymal Stem Cell Exosome Therapy in Treating Androgenetic Alopecia: A Clinical Trial Study Research Square (Research Square) · 2024
    23. Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Stem Cell Research & Therapy · 2025
    24. Single‐Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells‐Derived Exosomes to Androgenetic Alopecia The FASEB Journal · 2025
    25. The Anti-Aging Effects of Adipose-Derived Mesenchymal Stem Cell Exosomes on Skin and Their Potential for Personalized Skincare Applications Clinical Cosmetic and Investigational Dermatology · 2025 · 1 citations
    26. miR‐200a‐3p in Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Attenuates UVB‐Induced Skin Inflammatory Response and Oxidative Stress via Keap1‐Nrf2 Pathway Stem Cells International · 2025
    27. Advancing human adipose-derived mesenchymal stem cell-derived exosomes for androgenetic alopecia: Appraisal and methodological recommendations World Journal of Stem Cells · 2025
    28. Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway Journal of Translational Internal Medicine · 2024
    29. Adipose-derived stem cell exosomes promote critical-sized bone defect repair by enhancing the homing of bone marrow mesenchymal stem cells 2026
    30. Dermoelectroporation-Enhanced Delivery of Human Placental Mesenchymal Stem Cell-Derived Exosomes for Regenerative Applications: A Systematic Review and Meta-Analysis Journal of Surgery · 2025