Chitosan Hydrogel Dressing Loaded With Adipose Mesenchymal Stem Cell-Derived Exosomes Promotes Skin Full-Thickness Wound Repair

The study investigates a composite wound dressing (Exo/Gel) made from chitosan hydrogel and adipose mesenchymal stem cell-derived exosomes (ADMSC–Exo) to enhance full-thickness skin wound repair. The Exo/Gel dressing facilitates slow release of exosomes as the hydrogel degrades, promoting cell migration and angiogenesis in vitro. In a rat skin wound model, the dressing improved collagen deposition, angiogenesis, and hair follicle regeneration, demonstrating its potential to accelerate skin wound healing and offering a promising strategy for developing advanced wound dressings.