June 2025 in “Journal of Applied Toxicology” In this study, finasteride reduced oxidative stress, apoptosis, and inflammation in liver, kidney, and testis tissues of diabetic rats while boosting antioxidants, indicating potential protective effects that require further human trials for clinical application.
This study found that olive leaves extract significantly decreased prostate index, serum PSA, testosterone, and DHT levels in male rats with testosterone-induced benign prostatic hyperplasia, and showed potential as a therapeutic option due to its positive effects on prostate histology and antioxidant activity.
January 2025 in “Skin Pharmacology and Physiology” This study found that alopecia areata patients have elevated oxidative stress markers, such as OSI and MDA, and reduced antioxidant enzyme activities, suggesting a significant role for oxidative stress in the disease and potential value in targeting it therapeutically.
December 2024 in “Minia Journal of Medical Research” In this study, researchers found that alopecia areata patches with white hair follicles showed a significant decline in Sox10 marker expression compared to patches without white hairs, while other melanocytic markers were similarly expressed in both groups.
This study found that oxidative stress markers, specifically MDA and H2O2, along with decreased SOD activity, may play a key role in the development of diffuse hair loss in the studied population.
April 2024 in “Research Square (Research Square)” In this randomized trial, lupus patients taking daily 200 μg selenium supplements for eight weeks showed significant improvements in metabolic markers like CRP, ESR, MDA, and GPX, as well as reduced clinical symptoms such as arthritis and alopecia, compared to those receiving a placebo.
April 2024 in “Histochemistry and cell biology” In this study, NAC was observed to counteract the negative effects of cyclophosphamide on hair follicles in mice, preserving both biochemical parameters and hair structure, suggesting its potential as a therapeutic option for chemotherapy-induced hair loss.
In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.
August 2022 in “Turkish journal of veterinary research” This study found that dogs with clinical demodicosis experienced oxidative stress, indicated by higher MDA (a marker of oxidation) and lower antioxidant levels, compared to control and post-treatment groups.
April 2022 in “Journal of applied science and environmental management” This study found that Aframomum melegueta seed extract improved wound healing in albino rats, with treated groups showing smaller wound sizes and formation of new tissues compared to controls.
May 2021 in “Open Access Macedonian Journal of Medical Sciences” This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels.
September 2020 in “Benha Veterinary Medical Journal” This study found that non-infectious skin conditions in sheep were associated with oxidative stress and changes in trace elements, vitamin A, and immunoglobulin levels.
March 2020 in “The Egyptian Journal of Histology” This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.
February 2018 in “Egyptian Journal of Radiation Sciences and Applications” This study observed that Egyptian patients with discoid lupus erythematosus have significantly lower serum vitamin D3 and antioxidant levels compared to healthy controls, suggesting potential benefits of vitamin D3 and antioxidant supplementation.
December 2012 in “Bulletin of Egyptian Society for Physiological Sciences” This study found that topical application of copper (II) albumin complex improved healing signs in rats with full thickness thermal burns, enhancing antioxidant, anti-inflammatory, and pain modulating effects.
In scalded rats, this study found that early melatonin administration may reduce oxidative stress and inflammation, thus protecting hair follicle cells after severe burns.
January 2006 in “Chinese Journal of Aesthetic Medicine” This study found that exogenous zinc improved the viability of ultralong random skin flaps in Wistar rats by reducing oxidative damage and increasing protective protein levels.
January 2005 in “The Chinese Journal of Dermatovenereology” In this study, sodium fluoride at certain concentrations increased the MDA levels in cultured human hair follicles, while 0.01 mmol/L sodium selenite reduced this effect at lower fluoride concentrations.
January 2005 in “China Surfactant Detergent & Cosmetics” This study found that applying black mud to mice increased skin collagen and superoxide dismutase activity, decreased malondialdehyde levels, and enhanced hair growth and smoothness.
January 2023 in “Cutaneous and Ocular Toxicology” This study found that ATP may help reduce ribociclib-induced skin damage in rats by mitigating biochemical changes associated with oxidative stress.
December 2021 in “Egyptian Journal of Dermatology and Venereology” This study found that patients with female pattern hair loss had higher oxidative stress levels and lower antioxidant enzyme activities than healthy controls, suggesting oxidative stress may play a key role in disease progression.
January 2021 in “Medicine Science | International Medical Journal” This study found that men with early androgenetic alopecia had significantly lower total antioxidant capacity compared to healthy age-matched controls.
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November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
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August 2019 in “Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan” In this study on New Zealand white rabbits, the researchers reported that a hair tonic formula combining bitter melon leaf and carrot extracts resulted in optimal hair growth, particularly at a 3:1 ratio and a concentration of 3%, without causing irritation.
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April 2022 in “Applied sciences” This study reports the development of a microemulsion using Momordica charantia extract, which demonstrated strong antioxidant and 5α-reductase inhibitory activity, potentially aiding hair loss management. The microemulsion was stable over 12 weeks, suggesting its future potential for cosmetic or pharmacological applications.
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December 2021 in “Jurnal Insan Farmasi Indonesia” This study found that pomade containing 12% ethanol extract of Momordica charantia L. leaves promoted hair growth more effectively in male white rats compared to lower concentrations and a control.
December 2025 in “Zona Kebidanan Program Studi Kebidanan Universitas Batam” In this study, postpartum mothers using bitter melon fruit masks reported a significant reduction in hair loss, with 26 out of 30 participants experiencing improvements, as analyzed by the Wilcoxon test (p < 0.001).
This study found that a hair mask made from bitter gourd effectively reduced hair loss and dandruff among participants, though the authors note the need for clinical trials and durability tests for further validation.
July 2022 in “Forte Journal” In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.
March 2021 in “Egyptian Journal of Chemistry” In this study, researchers analyzed a herbal shampoo containing Momordica charantia extract and Hibiscus Rosa-Sinensis, noting it could support collagen development and hair growth. The shampoo, tailored to various hair and scalp conditions, was confirmed free of certain harmful heavy metals.