Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study

    April 2024 in “ Histochemistry and cell biology ”
    Yomna F. Hassan, Dalia A. Shabaan
    Studysummary In this study, NAC was observed to counteract the negative effects of cyclophosphamide on hair follicles in mice, preserving both biochemical parameters and hair structure, suggesting its potential as a therapeutic option for chemotherapy-induced hair loss.
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    Research cited in this study 11

    1. Alopecias: Practical Tips for the Management of Biopsies and Main Diagnostic Clues for General Pathologists and Dermatopathologists Journal of Clinical Medicine · 2023
    2. BMI1 Is Required for Melanocyte Stem Cell Maintenance and Hair Pigmentation Pigment Cell & Melanoma Research · 2023
    3. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023
    4. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    5. Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of Early-Onset Androgenetic Alopecia in Men QJM: An International Journal of Medicine · 2021
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    7. Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy Nature Communications · 2019
    8. An Asian Traditional Herbal Complex Containing Houttuynia Cordata Thunb, Perilla Frutescens Var. Acuta, and Green Tea Stimulates Hair Growth in Mice BMC Complementary and Alternative Medicine · 2017
    9. Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice Environmental Toxicology and Pharmacology · 2016
    10. Into the Redox Control: N-Acetyl-Cysteine Pleiotropic Effects from the Laboratory to Clinical Applications Acupuncture and related therapies · 2013
    11. Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia Cancer investigation · 1992