Measurement of Level of Vitamin D and Antioxidants in Discoid Lupus Erythematosus Patients

    February 2018 in “ Egyptian Journal of Radiation Sciences and Applications ”
    Dina F. Elessawi, Nashwa K. Radwan, Iman H. Bassyouni
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    TLDR Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.
    In a study involving 20 patients with Discoid Lupus Erythematosus (DLE) and 20 healthy controls, researchers found that serum levels of vitamin D3, superoxide dismutase (SOD), and glutathione peroxidase (GPX) were significantly lower in DLE patients, while malondialdehyde (MDA), a marker of oxidative stress, was significantly higher. There was a negative correlation between vitamin D3 levels and MDA, and a positive correlation between vitamin D3 and antioxidant enzymes SOD and GPX. The results suggest that vitamin D3 and antioxidant levels are disrupted in Egyptian DLE patients and that there is an association between these levels and disease activity. The study recommends routine vitamin D3 and antioxidant supplementation for DLE patients to improve prognosis.
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