TLDR Selenium supplements can help improve symptoms and metabolic markers in lupus patients.
A double-blind randomized controlled trial involving 50 SLE patients found that daily supplementation with 200 μg of selenium for 8 weeks significantly improved several metabolic markers and clinical manifestations. Specifically, selenium reduced serum high-sensitive reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), Malondialdehyde (MDA), and increased Glutathione peroxidase (GPX) and total antioxidant capacity (TAC), with p-values ˂0.001 for most parameters. Clinical symptoms such as arthritis (p=0.012) and alopecia (p=0.011) also showed improvement. This suggests selenium supplementation could be beneficial for lupus patients.
3 citations,
June 2023 in “Frontiers in medicine” Oxidative stress may contribute to hair loss in alopecia areata and antioxidants could potentially help as a treatment.
15 citations,
January 2023 in “Antioxidants” Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.
3 citations,
July 2022 in “Indian journal of dermatology, venereology, and leprology” Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.
5 citations,
May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
February 2018 in “Egyptian Journal of Radiation Sciences and Applications” Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.
10 citations,
April 2019 in “Environmental Science and Pollution Research” Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.
15 citations,
January 2023 in “Antioxidants” Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.
73 citations,
January 2013 in “European journal of dermatology/EJD. European journal of dermatology” Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.
