TLDR Selenium supplements can help improve symptoms and metabolic markers in lupus patients.
A double-blind randomized controlled trial involving 50 SLE patients found that daily supplementation with 200 μg of selenium for 8 weeks significantly improved several metabolic markers and clinical manifestations. Specifically, selenium reduced serum high-sensitive reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), Malondialdehyde (MDA), and increased Glutathione peroxidase (GPX) and total antioxidant capacity (TAC), with p-values ˂0.001 for most parameters. Clinical symptoms such as arthritis (p=0.012) and alopecia (p=0.011) also showed improvement. This suggests selenium supplementation could be beneficial for lupus patients.
3 citations,
June 2023 in “Frontiers in medicine” Oxidative stress may contribute to hair loss in alopecia areata and antioxidants could potentially help as a treatment.
15 citations,
January 2023 in “Antioxidants” Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.
3 citations,
July 2022 in “Indian journal of dermatology, venereology, and leprology” Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.
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5 citations,
May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
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February 2018 in “Egyptian Journal of Radiation Sciences and Applications” Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.
10 citations,
April 2019 in “Environmental Science and Pollution Research” Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.
15 citations,
January 2023 in “Antioxidants” Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.
73 citations,
January 2013 in “European journal of dermatology/EJD. European journal of dermatology” Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.
