Alterations in Transcriptome and Antioxidant Activity of Naturally Aged Mice Exposed to Selenium-Rich Rice
April 2019
in “
Environmental Science and Pollution Research
”
Studysummary In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits. Our plain-language summary of this paper — not a Tressless recommendation.
The study from April 29, 2019, examined the impact of selenium-rich rice on gene expression and antioxidant activity in naturally aged mice. The mice fed with selenium-rich rice showed improved antioxidant abilities, with higher levels of superoxide dismutase (SOD) and lower levels of malondialdehyde (MDA) in their serum and liver, indicating better oxidative stress management. They also experienced less hair loss and had denser fur. RNA sequencing revealed 53 differentially expressed genes related to various biological processes, including immune response and longevity. The study found that selenium-rich rice enhanced antioxidant activity and positively affected aging phenotypes in mice, suggesting that organic selenium from this rice could be beneficial for animal health. However, the study recommended further molecular research to fully understand the metabolic pathways involved.
