Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

Genetic studies on hair traits can improve understanding of health and disease.

This study explored the genetic basis of fiber diameter in alpacas, identifying candidate genomic regions including four significant areas on VPA6, VPA9, VPA29, and an unassigned scaffold, using whole genome association analysis and a custom SNP microarray.

This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

This study identified specific genetic markers related to wool quality in Rambouillet sheep, which may aid breeders in making informed selection and breeding decisions for improved fine wool production.

This study found that some white or grey human hairs can naturally regain pigmentation, suggesting a potential temporary reversibility of hair greying associated with stress and molecular changes.

In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.

This study found that constitutive activation of Stat3 in transgenic mice led to impaired hair growth and structural disorganization due to aberrant regulation of hair follicle and cytoskeletal genes.

In this study, researchers found two non-synonymous SNPs in the TERT gene associated with mean wool staple strength in sheep, suggesting TERT as a potential candidate gene for improving wool traits.

This review summarizes how single-cell omics technologies have advanced understanding of cellular regulatory programs in sheep and goats, but highlights limitations in genomic annotation and integration with population genetics for molecular breeding.

This study identified increased expression of ACAA1 and its regulation by hsa-miR-1343-3p, linking androgenetic alopecia to lipid metabolism pathways, particularly through PPAR signaling, in scalp tissues.

In this study, researchers developed a novel nucleic acid nanoparticle system incorporating quercetin, which they found enhances functional hair follicle regeneration and maintains epithelial structure stability in androgenetic alopecia by regulating hair follicle stem and dermal papilla cells.

This study examined how melatonin affects cashmere growth in goats, identifying potential molecular targets like ATP6V0A4, DLX3, and SMOC2 for enhancing cashmere yield and quality.

In this study, researchers reported that specific gene polymorphisms in Jiangnan cashmere goats, particularly SNPs in the HOXC13 and WNT4 genes, were significantly associated with key economic traits like birth weight and yearling weight, providing molecular markers for breeding and enhancing economic trait stability.

In this study, researchers using Astral—DIA proteomics technology identified 67 differentially expressed proteins in Gansu alpine fine-wool sheep, linking proteins like keratin and MGST3 in pathways to wool fineness regulation, particularly highlighting their association with hair follicle development.

This study demonstrated that Periplaneta americana extract significantly promoted hair regeneration in depilated mice by enhancing superoxide dismutase activity, upregulating vascular endothelial growth factor, modulating the FOXO/PI3K/AKT pathway, and restoring skin microbiome balance, suggesting its potential as a novel therapeutic candidate for alopecia.

This review explores melatonin's role in hair follicle cycles and its molecular mechanisms that enhance antioxidant capacity and modulate gene expression, offering potential strategies to improve cashmere production and treating human alopecia, according to the authors.

This review highlights the critical role of mitochondrial dysfunction in hair loss, particularly androgenetic alopecia, and explores potential therapies targeting mitochondrial pathways to improve hair health, underscoring the need for further research in this area.

In this study, researchers identified thousands of mRNA, lncRNA, circRNA, and miRNA transcripts involved in different hair follicle stages of Rex rabbits and highlighted significant gene expression changes and pathway enrichments, providing insights into the regulatory mechanisms of hair development in these animals.

This study identified key proteins, FKBP10 and FBN2, that promote the growth cycle of secondary hair follicles in cashmere goats, with higher expression in the anagen phase, offering insights into mechanisms potentially enhancing cashmere yield and quality.

This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.

This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.

This study found that DNA methylation may regulate the differential expression of the BMP7 gene in Hu sheep lamb skin of different patterns, and it influences the proliferation and cell cycle of dermal papilla cells, with demethylation treatment increasing BMP7 expression and cell proliferation.

This study found that the PLEE method increased hair protein extraction efficiency threefold and that bleaching hair reduced the coverage of keratin and associated proteins, leading to poorer hair quality, though it did not affect the overall protein identification.

In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.

This source reviews popular cosmeceutical ingredients for skin care, noting that while they are popular among consumers for anti-aging benefits, many lack robust clinical evidence for their efficacy and safety, as they are not regulated by the FDA.

In this study, researchers used proteomic and metabolomic analyses to explore hair follicle development in embryonic cashmere goats, identifying significant roles for the oxytocin signalling pathway and associated networks in this process.

In this study, researchers observed that heat stress significantly affected hair and skin traits in two indigenous goat breeds, with Kodi Aadu goats demonstrating greater thermal resilience compared to Kanni Aadu goats, potentially due to differences in gene expression and methylation.

In this study, N. ottonis cactus cell extract applied to mice promoted hair growth and increased the number of hair follicles, suggesting its potential as a hair-growth-promoting agent.

This study found that some white or grey hairs can naturally regain pigmentation, suggesting hair greying may be reversible in certain conditions linked to psychological stress.

This study found that collagen peptides from Mozambique tilapia significantly promoted hair regrowth and increased the proliferation of hair growth factors in vitro and in vivo, suggesting potential as supplements for hair loss prevention.