Single-Cell Omics Advances in Understanding Tissue Development and Complex Trait Formation in Sheep and Goats

    June 2026 in “ Animals ”
    Jianfang Wang, Haobin Ma, Diba Dedacha Jilo … Yongbin Liu
    Studysummary This review summarizes how single-cell omics technologies have advanced understanding of cellular regulatory programs in sheep and goats, but highlights limitations in genomic annotation and integration with population genetics for molecular breeding.
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    Research cited in this study 9

    1. A Single-Cell Transcriptomic Atlas Elucidates the Hair Cycle and Apoptosis Mechanisms in Goat Hair Follicles Frontiers in Cell and Developmental Biology · 2025
    2. Multiple Cell Types Guided by Neurocytes Orchestrate Horn Bud Initiation in Dairy Goats Genetics Selection Evolution · 2025
    3. The Molecular Anatomy of Cashmere Goat Hair Follicle During Cytodifferentiation Stage BMC Genomics · 2024
    4. Single-Cell Sequencing Technology in Ruminant Livestock: Challenges and Opportunities Current Issues in Molecular Biology · 2024
    5. Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep International journal of molecular sciences · 2024
    6. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    7. Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature Frontiers in cell and developmental biology · 2021
    8. Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber Frontiers in Genetics · 2021
    9. CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep ˜The œFEBS journal · 2017