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    A Single-Cell Transcriptomic Atlas Elucidates the Hair Cycle and Apoptosis Mechanisms in Goat Hair Follicles

    November 2025 in “ Frontiers in Cell and Developmental Biology ”
    Chongyan Zhang, Feng Yang, Zhihong Liu
    Studysummary This study mapped a detailed genetic profile of goat hair follicle apoptosis, identifying key genes and regulatory factors involved in the hair cycle, offering new insights into programmed cell death.
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    Research cited in this study 13

    1. A Probabilistic Boolean Model on Hair Follicle Cell Fate Regulation by TGF-Beta Biophysical Journal · 2022
    2. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    3. Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration Developmental Cell · 2021
    4. Expression and Localization of Sox10 During Hair Follicle Morphogenesis and Induced Hair Cycle International Journal of Medical Sciences · 2021
    5. Deficiency of Crif1 in Hair Follicle Stem Cells Retards Hair Growth Cycle in Adult Mice PloS one · 2020
    6. An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats Genes · 2019
    7. TGF-β and HSP70 Profiles During Transformation of Yak Hair Follicles from Anagen to Catagen Stage Journal of cellular physiology · 2019
    8. Differential Expression of Phospho-S6 in Hair Follicle Tumors: Evidence of Mammalian Target of Rapamycin Pathway Activation Journal of cutaneous pathology · 2019
    9. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    10. The Circadian Clock in Skin Journal of Biological Rhythms · 2015
    11. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    12. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    13. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 Journal of biological chemistry/˜The œJournal of biological chemistry · 2001