Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case
October 2024
in “
Frontiers in Medicine
”
single-cell sequencing sun-exposed skin unexposed skin PD-L1 PD-1 checkpoint pathway MAPK pathway TNF-alpha TGF-beta apoptosis pathways hair follicle cells photoaged skin UV-induced skin cancers programmed death-ligand 1 programmed cell death protein 1 mitogen-activated protein kinase tumor necrosis factor-alpha transforming growth factor-beta
Studysummary This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.
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