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research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis

148 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.

research Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism

51 citations , September 2008 in “Journal of Investigative Dermatology”

This article reviews the role of vitamin D receptor in protecting the skin from UV radiation-induced damage and tumor formation, but it reports no new clinical results.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

This study reported that UVR induced PKCε phosphorylation of Stat3 in transgenic mice, suggesting a role in enhancing sensitivity to UVR-related skin cancer development.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

research The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin

18 citations , April 2010 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.

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Community Join

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community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

in Research/Science 64 upvotes 2 years ago

The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community When the finasteride works but minoxidil doesn't

2203 upvotes 9 months ago

Finasteride maintains existing hair, but Minoxidil is less effective on hairlines. Walton Goggins is admired for his receding hairline, possibly using Finasteride and Minoxidil without a hair transplant.

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Learn

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learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

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Clinics

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36
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin