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    Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration

    September 2025 in “ Drug Design Development and Therapy ”
    Eduardo Anitua, Roberto Tierno, Gorka Orive, Mohammad Hamdan Alkhraisat
    Studysummary This study suggests that while platelet-rich products show promise in treating dermatological conditions like chronic wounds and skin aging, there is still a need for standardized methodologies and extensive trials to confirm their long-term clinical benefits.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 20

    1. Update on Platelet-Rich Plasma and Platelet-Rich Fibrin for Dermatologic Surgery: Addressing Knowns and Unknowns Dermatologic Surgery · 2024
    2. Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care Advanced Healthcare Materials · 2024
    3. Effectiveness of Platelet-Rich Plasma in Treating Female Hair Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Skin Research and Technology · 2024
    4. Is Autologous Platelet-Rich Plasma Capable of Increasing Hair Density in Patients with Androgenic Alopecia? A Systematic Review and Meta-Analysis of Randomized Clinical Trials Anais Brasileiros de Dermatologia · 2024
    5. Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials Stem cell research & therapy · 2024
    6. The Biological Role of Platelet Derivatives in Regenerative Aesthetics International journal of molecular sciences · 2024
    7. Advances in Platelet Rich Plasma-Derived Extracellular Vesicles for Regenerative Medicine: A Systematic-Narrative Review International Journal of Molecular Sciences · 2023
    8. The Use of Platelet-Rich Plasma in Wound Healing and Vitiligo: A Systematic Review and Meta-Analysis Skin Research and Technology · 2023
    9. Platelet-Rich Plasma and Acellular Dermal Matrix in the Surgical Treatment of Hidradenitis Suppurativa: A Comparative Retrospective Study Journal of Clinical Medicine · 2023
    10. Current Status of PRP Manufacturing Requirements and European Regulatory Frameworks: Practical Tools for the Appropriate Implementation of PRP Therapies in Musculoskeletal Regenerative Medicine Bioengineering · 2023
    11. Platelet-Rich Plasma-Loaded Bioactive Chitosan@Sodium Alginate@Gelatin Shell-Core Fibrous Hydrogels With Enhanced Sustained Release of Growth Factors for Diabetic Foot Ulcer Healing International Journal of Biological Macromolecules · 2023
    12. An Injectable Bioactive Dressing Based on Platelet-Rich Plasma and Nanoclay: Sustained Release of Deferoxamine to Accelerate Chronic Wound Healing Acta Pharmaceutica Sinica B · 2022
    13. The Combination of Platelet-Rich Plasma With Botulinum Toxin A in the Treatment of Hyaluronic Acid Embolic Cutaneous Necrosis and Alopecia Dermatologic Therapy · 2022
    14. Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia Expert Opinion on Biological Therapy · 2020
    15. Platelet-Rich Plasma: Current Applications in Dermatology PubMed · 2019
    16. Platelet-Rich Plasma, a Powerful Tool in Dermatology Journal of Tissue Engineering and Regenerative Medicine · 2019
    17. Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin JAMA Dermatology · 2018
    18. Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration Plastic and reconstructive surgery/PSEF CD journals · 2016
    19. Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology Journal of Cosmetic Dermatology · 2015
    20. Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways Journal of Cosmetic Dermatology · 2013