An Injectable Bioactive Dressing Based on Platelet-Rich Plasma and Nanoclay: Sustained Release of Deferoxamine to Accelerate Chronic Wound Healing

November 2022 in “ Acta Pharmaceutica Sinica B ”

Jiao Zhang, Qian Luo, Qian Hu, Tiantian Zhang, Jingyu Shi, Li Kong, Dehao Fu, Conglian Yang, Zhiping Zhang

platelet-rich plasma nanoclay deferoxamine angiogenesis macrophage polarization PRP

Studysummary This study reported that an injectable hydrogel based on platelet-rich plasma and laponite improved wound healing in diabetic and normal rats by enhancing angiogenesis and macrophage polarization.

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The study developed an injectable hydrogel (DPLG) combining platelet-rich plasma (PRP) and laponite to address limitations in PRP gels for wound healing, particularly in diabetic wounds. This hydrogel overcame issues of non-injectability and rapid degradation by allowing sustained release of growth factors and deferoxamine, promoting angiogenesis. In experiments with type I diabetic and normal rats, DPLG effectively accelerated wound healing by enhancing macrophage polarization and angiogenesis. The study suggested that DPLG could serve as a simple and effective bioactive dressing for chronic wound treatment.

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