An Injectable Bioactive Dressing Based on Platelet-Rich Plasma and Nanoclay: Sustained Release of Deferoxamine to Accelerate Chronic Wound Healing

The study developed an injectable hydrogel (DPLG) combining platelet-rich plasma (PRP) and laponite to address limitations in PRP gels for wound healing, particularly in diabetic wounds. This hydrogel overcame issues of non-injectability and rapid degradation by allowing sustained release of growth factors and deferoxamine, promoting angiogenesis. In experiments with type I diabetic and normal rats, DPLG effectively accelerated wound healing by enhancing macrophage polarization and angiogenesis. The study suggested that DPLG could serve as a simple and effective bioactive dressing for chronic wound treatment.